is a comprehensive adrenal and HPA axis support formula combining four standardized adaptogenic botanicals, five bovine and porcine glandular extracts, adrenal-specific vitamins and minerals, and Alpha Lipoic Acid in a single daily two-capsule serving, designed to nourish the neuro-endocrine pathways that govern stress resilience, energy, mood, immune function, hormonal balance, and metabolic stability.

The adrenal glands and the HPA (hypothalamic-pituitary-adrenal) axis form the central command system of the body's stress response. When cortisol is called upon repeatedly and the adrenal glands cannot keep pace with demand, the downstream consequences extend far beyond fatigue. Thyroid hormone conversion slows. Immune surveillance weakens. Sleep architecture deteriorates. Hormonal production declines. Mood becomes fragile. Blood sugar regulation destabilizes. And the body's capacity to recover from the next stressor is reduced, creating a cycle of progressive depletion that most single-ingredient adrenal supplements cannot adequately address.

Adrenal Synergy was formulated for this complexity. The four adaptogens, Ashwagandha, Rhodiola, Eleuthero, and Asian Ginseng, each work through distinct mechanisms on the HPA axis to modulate the stress response, support adrenal cortical function, and rebuild resilience over time. The glandular complex, including Suprarenal Adrenal (Porcine), Suprarenal Cortex (Bovine), Pituitary (Bovine), Hypothalamus (Bovine), and Thymus (Bovine), provides direct glandular tissue support through the nutritional and signaling compounds naturally concentrated in these organs, a cornerstone of glandular therapy used in integrative and functional medicine for decades. The nutrient matrix, Vitamin C, B6 as P5P, Methylfolate, Pantothenic Acid, and Zinc, directly nourishes the adrenal tissue and enzymatic pathways involved in cortisol and catecholamine synthesis. And the DGL Licorice and Alpha Lipoic Acid round out the formula with cortisol-modulating and antioxidant support.Contains porcine and bovine glandular extracts. Not suitable for those avoiding animal-derived ingredients. Non-GMO. Gluten-free. Vegetable capsule (hypromellose). 60 capsules, 30 servings at 2 capsules daily.

Key Benefits:

• Supports healthy adrenal gland function and HPA axis balance
• Promotes healthy cortisol metabolism and balanced stress response
• Supports sustained energy and reduced stress-related exhaustion
• Supports healthy mood, cognitive clarity, and emotional resilience under stress
• Promotes healthy immune function via thymus glandular support
• Supports healthy hypothalamic-pituitary signaling for neuro-endocrine balance
• Supports healthy thyroid function indirectly via HPA axis regulation
• Supports healthy sleep quality by addressing adrenal-driven cortisol dysregulation
• Supports healthy hormonal production and balance
• Supports healthy blood sugar and metabolic stability under stress
• Four standardized adaptogenic botanicals address the stress response through distinct and complementary pathways
• Five glandular extracts provide direct adrenal, pituitary, hypothalamus, and thymus support
• Active nutrient matrix including P5P, Methylfolate, and Pantothenic Acid directly nourishes adrenal tissue
• Vegetable capsule, non-GMO, gluten-free

What's Inside — Full Supplement Facts (per 2-capsule serving):

Vitamin C (as Ascorbic Acid) — 50 mg — The adrenal glands contain the highest concentration of Vitamin C in the body. Vitamin C is required for cortisol synthesis and is rapidly depleted during acute and chronic stress. Replenishing Vitamin C supports adrenal tissue health and cortisol production capacity.

Vitamin B6 (as Pyridoxal-5-Phosphate) — 1 mg — The active coenzyme form of B6. Essential for adrenal catecholamine synthesis, including the enzymatic conversion of tyrosine to dopamine, norepinephrine, and epinephrine, the stress hormones produced by the adrenal medulla.

Folate (as Methyltetrahydrofolic Acid) — 50 mcg — Active methylfolate supporting the methylation cycle that drives adrenal hormone metabolism, healthy homocysteine processing, and neurotransmitter synthesis.

Pantothenic Acid (as d-Calcium Pantothenate) — 50 mg — The single most essential B vitamin for adrenal function. Pantothenic Acid is required for Coenzyme A synthesis, the central cofactor for steroid hormone production in the adrenal cortex.

Zinc (as Zinc AAC) — 1 mg — An essential cofactor for adrenal enzyme activity, immune function, and the antioxidant defense systems that protect adrenal tissue from the oxidative burden of cortisol synthesis.

Suprarenal Adrenal (Porcine) — 50 mg — Porcine adrenal glandular extract providing the naturally occurring nutritional and signaling compounds concentrated in adrenal tissue. Used in glandular therapy to provide direct adrenal support through the tissue-specific compounds that support adrenal function and recovery.

Suprarenal Cortex (Bovine) — 100 mg — Bovine adrenal cortex extract providing the cortical layer of the adrenal gland, which is responsible for cortisol, aldosterone, and DHEA production. Adrenal cortex glandular has a longer history of use in functional medicine than whole adrenal glandular for supporting cortisol pathway recovery.

Organic Ashwagandha Root Extract (standardized 5% withanolides) — 100 mg — A premier adaptogen supporting healthy HPA axis function, cortisol modulation, thyroid hormone T4-to-T3 conversion, and adrenal recovery during periods of sustained demand.

Pituitary (Bovine) — 100 mg — Bovine anterior pituitary glandular extract providing support for the pituitary gland's signaling role in the HPA axis. The pituitary produces ACTH (adrenocorticotropic hormone), which signals the adrenals to produce cortisol, and pituitary glandular is used in integrative medicine to support healthy HPA axis signaling capacity.

Rhodiola Root Extract (standardized 3% Rosavin, 1% Salidroside) — 100 mg — A Scandinavian and Siberian adaptogen extensively studied for HPA axis modulation, stress resilience, cognitive performance under stress, anti-fatigue activity, and mitochondrial energy support. The standardized rosavin and salidroside content ensures consistent adaptogenic activity.

Licorice Root DGL Extract (standardized 3.0% Glycyrrhizinic Acid) — 75 mg — Deglycyrrhizinated licorice providing cortisol-modulating activity by inhibiting the enzyme (11-beta-HSD2) that breaks down cortisol, effectively extending the half-life of available cortisol and reducing adrenal demand. Particularly supportive during low-cortisol phases of HPA axis dysregulation.

Eleuthero Root Extract (standardized 0.8% Eleutheroside) — 50 mg — Siberian ginseng providing HPA axis modulation, enhanced physical and mental endurance, immune support, and adrenal resilience through a distinct mechanism from Ashwagandha and Rhodiola.

Asian Ginseng Aerial Parts (standardized 8% Ginsenosides) — 50 mg — An adaptogen supporting healthy HPA axis function, physical and cognitive performance under stress, and the regeneration of hypothalamic cortisol receptor sensitivity for improved self-regulation of cortisol levels.

Hypothalamus (Bovine) — 50 mg — Bovine hypothalamus glandular extract supporting the hypothalamic regulation of the HPA axis, including the production of CRH (corticotropin-releasing hormone) that initiates the cortisol cascade.

Thymus (Bovine) — 30 mg — Bovine thymus glandular extract supporting immune function and immune resilience. The thymus is the primary site of T-cell maturation and immune education, and thymus glandular is used in integrative medicine to support immune capacity that is frequently compromised by adrenal-driven cortisol dysregulation.

Alpha Lipoic Acid — 5 mg — A universal antioxidant active in both water and fat-soluble environments that supports adrenal tissue protection from oxidative stress and complements the glutathione-recycling activity needed during periods of high adrenal demand.

Other Ingredients: Hypromellose (vegetable capsule), Microcrystalline Cellulose, Certified Organic Rice Extract (organic rice hulls, organic gum arabic, organic sunflower oil, silica).

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Storage

Store in a cool, dry, tightly closed place. Keep out of reach of children.

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Directions

Take 2 capsules daily with meals, or as directed by your healthcare professional.If you are under 18, pregnant, nursing, taking medications, or have a medical condition, consult your healthcare practitioner before use. Contains porcine and bovine glandular extracts.

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