Methyl Folate Plus™ formula provides the two metabolically bioactive forms of folate. L-5- Methyl folate and Folinic Acid together with niacinamide deliver significant support to all areas of the folate methylation process. Bioactive folate is necessary for all cells to function normally but is especially important in the nervous system and immune system. Methylfolate is an important co-factor in the production of dopamine and serotonin while also being important in mitochondrial and detoxification support.

Elevated folic acid levels in the blood plasma can indicate poor methylation. This formula is also necessary for polymorphisms in the FOLR1/2, DHFR, MTHFD1, MTHFS and MTHFR genes.