Nucleoside-Analog-1 is a 4′-Azidocytidine analogue, used to against Hepatitis C virus replication.

Product information

CAS Number: 876707-99-2

Molecular Weight: 267.20

Formula: C9H9N5O5

Chemical Name: (2R,4R,5S,6S)-4-azido-5-hydroxy-4-(hydroxymethyl)-3,7-dioxa-1,9-diazatricyclo[6.4.0.0²,⁶]dodeca-8,11-dien-10-one

Smiles: [N-]=[N+]=N[C@]1(CO)O[C@@H]2[C@@H](OC3=NC(=O)C=CN32)[C@@H]1O

InChiKey: HXIRTOCBJXONPW-XZMZPDFPSA-N

InChi: InChI=1S/C9H9N5O5/c10-13-12-9(3-15)6(17)5-7(19-9)14-2-1-4(16)11-8(14)18-5/h1-2,5-7,15,17H,3H2/t5-,6-,7+,9+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 20 mg/mL (74.85 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Smith DB, et al. The design, synthesis, and antiviral activity of 4’-azidocytidine analogues against hepatitis C virus replication: the discovery of 4’-azidoarabinocytidine. J Med Chem. 2009 Jan 8;52(1):219-23.
2. Smith DB, et al. The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4’-azidocytidine against hepatitis C virus replication: the discovery of 4’-azido-2’-deoxy-2’-fluorocytidine and 4’-azido-2’-dideoxy-2’,2’-difluorocytidine. J Med Chem. 2009 May 14;52(9):2971-8.

Products are for research use only. Not for human use.