Will this hose work for both coolant and boost applications?

Yes. Silicone hose handles coolant temps and turbo boost pressure equally well. Just verify your clamp size matches the 2.50" diameter — standard hose clamps work fine.

Do I need to use a sealant or adhesive on the connections?

No adhesive needed. Slide the hose onto barbed fittings and tighten hose clamps at both ends. The 45-degree pre-form keeps the line rigid once seated and clamped.

Can this hose be routed through tight spaces, or does the fixed bend limit placement?

The 45-degree angle is fixed, so it works best for plumbing routes that naturally call for that bend. If your layout needs a sharper or gentler angle, standard flexible silicone hose is a better fit.