Do I need clamps and fittings to install this hose?

Yes. This is bare tubing—you'll need hose clamps and the appropriate fittings (barbed or threaded) to connect it to your system. Clamp size and fitting type depend on your application.

Can this handle boost pressure, or is it coolant-only?

Three-ply silicone tubing works for both boost and coolant lines. It resists oil and heat exposure, so it'll survive intercooler piping or vacuum-fed systems without degrading.

Do I need to prep or prime this before installation?

No prep needed. Install it as-is. If you're swapping old hose, clean the barbs on your fittings so the silicone seats tight and doesn't slip under pressure.