Syntrophin α1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91311-50, BS91311-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q13424(Human)

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, ICC, IF, IHC, FC

All Applications: WB:1:500
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:200

Background: The syntrophins are PDZ-domain-containing proteins that facilitate the recruitment of signaling proteins such as NOS1 to the dystrophin-associated protein complex. The syntrophin family are structurally related proteins that contain multiple protein interaction motifs. Syntrophins associate directly with dystrophin, the product of the Duchenne muscular dystrophy locus, and its homologs. α-Syntrophin has an important role in synapse formation and in the organization of utrophin, acetylcholine receptor and acetylcholinester-ase at the neuromuscular synapse. Specifically, NOS1 binds to α-Syntrophin at muscle sarcolemma. β2-Syntrophin is a modular adapter. In muscle cells, β2-Syntrophin interacts with members of the dystrophin family, which in-cludes utrophin.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: Syntrophin α1 polyclonal antibody detects endogenous levels of Syntrophin α1 protein.

Bioworld Molecular Weight: 54 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Syntrophin alpha 1 on SiHa cells lysates using anti-Syntrophin alpha 1 antibody at 1/1,000 dilution., ICC staining Syntrophin alpha 1 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: TACIP1, SNTA1, SNT1, 59 kDa dystrophin-associated protein A1 acidic component 1, Acidic alpha 1 syntrophin, Alpha 1 syntrophin, Alpha-1-syntrophin, dJ1187J4.5, Dystrophin associated protein A1 59kDa acidic component, LQT12, OTTHUMP00000030650, Pro-TGF-alpha cytoplasmic domain-interacting protein 1, SNT1, Snta1, SNTA1, Syntrophin 1, Syntrophin-1, TACIP1,

Immunogen: Recombinant protein within human Syntrophin alpha 1 aa 1-200.

Conjugate: Unconjugated

Modification: Unmodified